BIOL-02. MODELING BRAIN TUMORS IN VIVO AND WITH HUMAN ORGANOIDS

Abstract Brain tumors are a large and heterogeneous group of neoplasms that affect the central nervous system include some deadliest cancers. Almost all conventional new treatments fail to hinder tumoral growth most malignant brain tumors. This is due multiple factors, such as intra-tumor heterogeneity, microenvironmental properties human brain, lack reliable models test therapies. Therefore, creating faithful for each tumor discovering tailored pose great challenges in fight against cancer. We have recently developed IPSCs-derived organoid model pediatric medulloblastoma high-grade glioma. These overcome limitations using animal pave way gaining unprecedented knowledge into development cancer system. Nevertheless, fill gap field it will be crucial use patient-derived tissues. To this aim, next years, we develop organoids (PDO) recapitulate several features primary tumors, heterogeneity genomic alternation. The production PDOs allow us generate important knowledge, discover potential drug targets, small molecules could exploited early-phase clinical trials, hopefully, validate treatments. Interestingly, possibility directly generated from also bases personalized