BIOL-02. MODELING BRAIN TUMORS IN VIVO AND WITH HUMAN ORGANOIDS
نویسندگان
چکیده
Abstract Brain tumors are a large and heterogeneous group of neoplasms that affect the central nervous system include some deadliest cancers. Almost all conventional new treatments fail to hinder tumoral growth most malignant brain tumors. This is due multiple factors, such as intra-tumor heterogeneity, microenvironmental properties human brain, lack reliable models test therapies. Therefore, creating faithful for each tumor discovering tailored pose great challenges in fight against cancer. We have recently developed IPSCs-derived organoid model pediatric medulloblastoma high-grade glioma. These overcome limitations using animal pave way gaining unprecedented knowledge into development cancer system. Nevertheless, fill gap field it will be crucial use patient-derived tissues. To this aim, next years, we develop organoids (PDO) recapitulate several features primary tumors, heterogeneity genomic alternation. The production PDOs allow us generate important knowledge, discover potential drug targets, small molecules could exploited early-phase clinical trials, hopefully, validate treatments. Interestingly, possibility directly generated from also bases personalized
منابع مشابه
Achievable accuracy in brain tumors by in vivo dosimetry with diode detectors
ABSTRACT Background: In vivo measurements of applied dose during radiotherapy treatment, is important to ensure accurate dose delivery to patients. Uncertainty in dose delivery should fall within ±5% of the prescribed dose as recommended by ICRU. Assessment of dose for radiotherapy applications performed with various types of detectors. In this study, semiconductor diodes were used which have s...
متن کاملTranslational potential of human brain organoids
The recent technology of 3D cultures of cellular aggregates derived from human stem cells have led to the emergence of tissue-like structures of various organs including the brain. Brain organoids bear molecular and structural resemblance with developing human brains, and have been demonstrated to recapitulate several physiological and pathological functions of the brain. Here we provide an ove...
متن کاملZika virus impairs growth in human neurospheres and brain organoids.
Since the emergence of Zika virus (ZIKV), reports of microcephaly have increased considerably in Brazil; however, causality between the viral epidemic and malformations in fetal brains needs further confirmation. We examined the effects of ZIKV infection in human neural stem cells growing as neurospheres and brain organoids. Using immunocytochemistry and electron microscopy, we showed that ZIKV...
متن کاملModeling Development and Disease with Organoids
Recent advances in 3D culture technology allow embryonic and adult mammalian stem cells to exhibit their remarkable self-organizing properties, and the resulting organoids reflect key structural and functional properties of organs such as kidney, lung, gut, brain and retina. Organoid technology can therefore be used to model human organ development and various human pathologies 'in a dish." Add...
متن کاملEvaluation of Diagnostic Value of CT Scan and MRI in Brain Tumors and Comparison with Biopsy
Abstract Background Cerebral neoplasm arises from brain, spinal cord and meningeal cells. Not only malignant cerebral neoplasm also benign tumor could lead to death due to mass effect on vital structures. Access to these tumors is difficult, and MRI and CT scan could be helpful in determining anatomical location of tumors and distinction of malignant from benign. Objective For better and ea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuro-oncology
سال: 2023
ISSN: ['1523-5866', '1522-8517']
DOI: https://doi.org/10.1093/neuonc/noad073.021